# Can I Take NR? Understanding Dosage and Guidelines Dosage [Nicotinamide riboside (NR)](https://decodeage.com/products/nr-300-30) is reported to be generally well-tolerated at doses ranging up to 3000mg of body weight daily. ### When to consume NR? Take one capsule daily, before midday. Research indicates that taking NR supplements in the morning may be optimal for enhancing their effectiveness. This timing aligns with the body's natural circadian rhythms (controls all physical, mental, and behavioural changes that follow a daily cycle), potentially improving cellular uptake and promoting ### Who should avoid taking NR? While NR is generally safe for adults, its effects on children and adolescents have not been extensively studied. Therefore, it is recommended that NR not be used in these populations without medical supervision. Individuals with certain medical conditions, particularly those affecting liver function or metabolic disorders, should consult a healthcare professional before starting NR. Pregnant or breastfeeding women should avoid NR supplementation. Individual responses to supplements can vary and it’s best to consult with a healthcare provider for personalized advice. --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://help.decodeage.com/decode-age-support/supplement-information/nicotinamide-riboside-nr/can-i-take-nr-understanding-dosage-and-guidelines.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.