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What is NR (β-NR 300 /Beta Nicotinamide Riboside)? How Does It Work?

What is NR?

Nicotinamide Riboside (NR) is a naturally occurring compound found in trace amounts in various foods such as milk and yeast.

It is a derivative of vitamin B3, also known as niacin, and plays a crucial role in boosting your body's levels of NAD+ (Nicotinamide Adenine Dinucleotide).

As a precursor to NAD+, NR boosts NAD+ levels, which tend to decline with age. Higher NAD+ supports cellular energy, DNA repair, metabolic health, and overall well-being.

Why is NR Important?

Nicotinamide riboside (NR) is gaining attention for its significant role in health and disease management due to its ability to elevate levels of nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in various metabolic processes.

Research indicates that NR supplementation can lead to numerous health benefits, including improved mitochondrial function, enhanced stem cell regenerative potential, and increased SIRT activity, which are vital for maintaining cellular health and longevity.

NR is important due to its role as a NAD+ precursor, its potential health benefits across various conditions, and its safety profile, making it a promising candidate for therapeutic use.

How is NR linked with Ageing?

Nicotinamide riboside (NR) has emerged as a significant compound in the context of aging, primarily due to its ability to boost levels of nicotinamide adenine dinucleotide (NAD+), which plays a crucial role in cellular metabolism and longevity

NAD+ levels naturally decline with age, which is associated with various age-related diseases and metabolic dysfunctions. Supplementing with NR can help restore NAD+ levels, potentially mitigating some effects of ageing.

What are NR Supplements?

Nicotinamide riboside (NR) supplements are a form of vitamin B3 that help increase levels of NAD+ (nicotinamide adenine dinucleotide) in the body. NAD+ is essential for energy production, DNA repair, and overall cellular health.

Foods that contain vitamin B3 include animal products like meat, fish, and poultry as well as plant-based sources like avocado, whole grains, and mushrooms, but not enough to significantly boost NAD+ levels in our bodies.

That’s why NR supplements have become popular. They offer a more concentrated dose of NR and are essential to maintain our falling NAD+ Levels.

What are the Benefits of NR Supplements?

  • Increases NAD+ Levels: NR effectively boosts NAD+ levels, supporting essential cellular processes.*

  • Enhances Muscle Function: May improve muscle strength and function by promoting mitochondrial health and energy production. *

  • Supports Cellular Energy: Boosts NAD+ to enhance mitochondrial function, leading to better cellular energy production. *

  • DNA Repair: Higher NAD+ levels activate enzymes responsible for DNA repair, aiding genomic stability and reducing cellular damage. *

  • Supports Cognitive Health: By increasing NAD+ levels, NR helps maintain neuronal health and supports cognitive function as we age. *

  • Promotes Healthy Aging: Elevated NAD+ levels contribute to improved cellular repair and maintenance, promoting healthy ageing. *

What are the Side effects of NR?

Chronic oral NR supplementation did not lead to severe side effects such as flushing, pruritus, hyperglycemia, hyperuricemia, or increased enzyme activity in the liver or muscle. NR has been tested in several clinical trials, where it was established as safe for both short-term and long-term use.

Individual responses to supplements can vary and it’s best to consult with a healthcare provider for personalized advice.

References

  • Mehmel, M., Jovanović, N., & Spitz, U. (2020). Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients, 12(6), 1616. https://doi.org/10.3390/nu12061616

  • Priyanka N Bushana, Michelle A Schmidt, Michael J Rempe, Barbara A Sorg, Jonathan P Wisor, Chronic dietary supplementation with nicotinamide riboside reduces sleep need in the laboratory mouse, SLEEP Advances, Volume 4, Issue 1, 2023, zpad044, https://doi.org/10.1093/sleepadvances/zpad044

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