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What are the benefits of taking TMG supplements?
What are the benefits of taking TMG supplements?

Learn about the benefits of Trimethylglycine (TMG) for optimal results and the impact on metabolism, cardiovascular health and side effects.

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Written by Maria D'costa
Updated over a week ago

TMG stands for trimethylglycine, a natural compound found in plants and animals. TMG supplements have become increasingly popular in recent years due to their potential health benefits. In this article, we will discuss the benefits, recommended dosage, and potential side effects of TMG supplements.

What is TMG?

Trimethylglycine (TMG) is a naturally occurring compound in the human body and certain foods such as beetroot. It is also available as a supplement and has gained popularity for its role in various bodily processes.

Provide Methylation Support

TMG serves a crucial role in methylation, a biochemical process involving the transfer of a methyl group (a carbon atom with three hydrogen atoms attached) onto a molecule. Comprising glycine, an amino acid, with three attached methyl groups, TMG plays a significant part in DNA production and expression. Methylation is instrumental in controlling the activation or deactivation of genes, influencing how cells grow, develop, and respond to external factors. Beyond gene expression, methylation regulates essential biological processes, including cell division, energy production, and nerve function.

How Does Methylation Influence Ageing?

Studies have shown that methylation patterns in gene expression regions tend to increase with age, and this can alter gene expression and lead to changes in cellular processes. An example is the regulation of telomeres, which are the protective caps at the end of our chromosomes. Telomeres shorten as we age, and this shortening is associated with various age-related diseases. Methylation plays a crucial role in regulating the length of telomeres, and changes in methylation patterns can accelerate telomere shortening, thus contributing to premature ageing (R).

Reduces homocysteine levels

TMG also converts an amino acid called homocysteine into methionine via methylation. Homocysteine is a byproduct of protein metabolism and high levels of it have been linked to an increased risk of cardiovascular disease, osteoporosis, arthritis, depression and dementia. By converting homocysteine into methionine, TMG helps to prevent potential damage.

Potential health benefits

  1. Reduces Homocysteine levels

    Research has shown that TMG may have a protective effect on the heart and may help reduce the risk of developing heart disease. It is believed that TMG helps lower levels of homocysteine, an amino acid that, in high levels, can increase the risk of heart disease and stroke. TMG may also act as an antioxidant, protecting against oxidative stress that can lead to damage of blood vessels and contribute to cardiovascular problems.

  2. Enhances Athletic Performance

    TMG has several benefits that make it an attractive supplement for athletes. First, it helps to increase the body’s production of creatine, which is essential for muscle strength and energy. This means that by taking TMG, athletes can improve their performance in high-intensity activities such as weightlifting or sprinting. TMG also works to improve blood circulation and oxygen delivery to the muscles, which can help with endurance and overall performance. Additionally, it has been shown to decrease fatigue and muscle soreness after intense workouts, allowing athletes to recover faster and train harder. (R)

  3. Insulin sensitivity

    Insulin sensitivity refers to how responsive the body's cells are to the effects of insulin, a hormone that plays a crucial role in regulating blood sugar levels. In people with insulin resistance, cells do not respond as well to insulin, leading to increased blood sugar levels and a higher risk of developing type 2 diabetes. Studies have shown that TMG may help improve insulin sensitivity by promoting the formation of a compound called S-adenosylmethionine (SAMe) which helps with insulin signalling and glucose metabolism. (R)

  4. Synnery with NMN

    NMN relies on methyl groups for proper functioning, and TMG aids in restoring these methyl groups. NMN is converted to nicotinamide (NAM) which is further methylated so that it can be passed via urine. The conversion of NMN to NAM involves methylation, leading to potential depletion of methyl groups. Therefore, supplementing NMN with TMG is an effective strategy to address this depletion.

The Benefits of Combining TMG and NMN

NMN is a precursor to the coenzyme NAD+, which is involved in various cellular processes, including DNA repair and energy production. NMN works synergistically with TMG to optimize the methylation process and provide additional health benefits.

By supporting the methylation process, NMN ensures that there is an adequate supply of SAMe, which is required for the activation of sirtuins and PARPs. These longevity-promoting genes play a crucial role in regulating cellular functions and have been linked to increased lifespan and improved overall well-being.

What are the possible side effects of taking TMG?

While TMG is generally considered safe for consumption, it may cause various side effects in some individuals. The most common side effects associated with TMG are digestive issues such as bloating, cramps, indigestion, nausea, vomiting, and diarrhoea. In addition, some individuals may also experience slight headaches.

In Conclusion

In summary, supplementing with TMG and NMN can have significant benefits for your overall health and well-being. TMG ensures the effective execution of the methylation process, while NMN supports the activation of longevity-promoting genes. Together, these two compounds work synergistically to optimize the methylation process and provide additional health benefits. As always, be sure to consult with your healthcare provider before adding any new supplements to your regimen.

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