Taking NMN While Fasting: Does It Work? A Guide to Benefits & Usage

Discover the effectiveness of NMN in enhancing longevity and health, both during fasting and as a regular supplementation.

Overview on NMN in fasting state.

NMN, also known as Nicotinamide Mononucleotide, has gained popularity for its potential health benefits. One common question among NMN users is whether it can be taken during fasting or on an empty stomach. Let's dive into this topic and explore the best ways to take NMN for optimal benefits.

Can I Take NMN During Fasting?

Many people practice different forms of fasting for various health reasons, such as weight loss or anti-ageing. Therefore, it's understandable to want to incorporate NMN into a fasting routine. The good news is that NMN is considered compatible with fasting, and taking it during fasting should not break the fast. Dr. David A. Sinclair, a renowned Harvard professor and expert in ageing, takes NMN with yoghurt in the morning, alongside resveratrol, and does not consider it as breaking his fast.

Benefits of NMN on an Empty Stomach

Recommended Intake Time

  • First Thing in the Morning: It is advised to take NMN on an empty stomach, ideally first thing in the morning, even if fasting. This helps maximize its absorption and effectiveness​​​​.

Potential Benefits

  • Activation of Longevity Pathways: NMN, particularly when combined with resveratrol, activates pathways like the Sirtuin Pathway, which are crucial in regulating lifespan and combating ageing​​.

  • Boosting Energy in Cells: NMN can be delivered directly into cells, even without converting to NAD+. This direct delivery provides a quicker path for cells to refuel, promoting cell division and growth, and combating cellular senescence associated with ageing​​.

  • Combatting Metabolic Diseases: NMN helps to boost NAD+ levels, which can helps manage conditions like diabetes, obesity, and non-alcoholic fatty liver disease, prevalent in older adults due to reduced NAD+ levels​​.

  • Reactivating Blood Flow: Studies have shown that NMN can reactivate compromised blood flow in ageing subjects, improving overall vascular health​​.

  • Enhancing Energy Metabolism: NMN aids in breaking down nutrients into energy, powering cell functions, and reducing oxidative stress, thereby potentially slowing the ageing process and repairing cellular damage​​.

If you choose to take NMN sublingually, it's important to note that some individuals may experience mild stomach upset or nausea when taking it on an empty stomach. In this case, consider taking NMN with a light meal to alleviate any discomfort.

Benefits of NMN Regardless of Fasting

Regardless of whether you take NMN during fasting or on an empty stomach, the potential benefits remain mostly the same.


In summary, NMN can be taken during fasting and on an empty stomach without breaking the fast. Taking it on an empty stomach may promote better absorption and bioavailability, but the choice ultimately depends on individual preferences and needs. Whether you take NMN during fasting or with food, the potential benefits remain the same. As always, consult with a healthcare professional before starting any new supplement regimen for personalized recommendations and to ensure your safety.

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