Difference between AKG, Ca-AKG, and AAKG and Why Ca-AKG Stands Out?

Get to know the difference between your favorite molecule AKG or Ca-AKG to find out the winner.

Introduction Alpha-ketoglutarate (AKG) is an important compound in the body, playing a vital role in the Krebs cycle and various metabolic and cellular pathways. It is a key player in energy production and various cellular functions. With its numerous health benefits, many people are considering supplementation for its effects, particularly in aging and longevity. However, there are different forms of AKG, which can be confusing for those looking to understand its potential. In this article, we will explore the differences between AKG, Ca-AKG, and AAKG, and why Ca-AKG stands out as the most effective form.

AKG: The Basic Form

As aforementioned, AKG is involved in various metabolic and cellular processes in the body. It serves as an intermediate in the Krebs cycle, which is crucial for energy production. However, when taken as a standalone supplement, ordinary alpha-ketoglutarate has limitations. Studies have shown that when taken orally, up to 80% of AKG is not effectively absorbed and does not reach the bloodstream. This significantly reduces its efficacy as a supplement.

AAKG: L-Arginine Bound to AKG

AAKG, or Arginine Alpha-Ketoglutarate, is a combination of L-arginine (an amino acid) and AKG. This formulation enhances the blood and hormone-enhancing properties of AKG. AAKG is considered superior to traditional AKG, but it still does not match the efficacy of Ca-AKG. AAKG is mostly used for its benefits in improving blood flow and supporting athletic performance.

Ca-AKG: Calcium Bound to AKG

Ca-AKG, or Calcium Alpha-Ketoglutarate, stands out as the most effective form of AKG. This compound binds AKG to calcium, an excitatory mineral, resulting in a supplement with higher bioavailability and stability. Ca-AKG is particularly noted for its longevity benefits and is used in clinical research for its potential in reversing biological aging and supporting heart and cell health. It is believed to increase AMPK activity, an energy sensor regulating cellular metabolism, while inhibiting mTOR, a protein regulating cell growth and metabolism.

Comparative Analysis of AKG Forms

If you're researching AKG supplements, you may have noticed that there are different forms available, such as Ca-AKG, AKG, and AAKG. To better understand the differences between these forms, let's take a closer look at their comparative analysis.


The bioavailability of a substance refers to how well it is absorbed and utilized by the body. When it comes to AKG, research has shown that Ca-AKG demonstrates higher bioavailability compared to AKG and AAKG. This is due to the addition of calcium, which helps enhance the absorption and utilization of AKG in the body. So, if you're looking for an AKG supplement that is easily absorbed and effectively utilized, Ca-AKG may be the best choice for you.

Longevity and Anti-Aging Benefits

In various studies, Ca-AKG has been linked with significant longevity and anti-aging benefits. It has shown promising results in extending lifespan and improving HealthSpan in animal models. This is due to the compound's ability to support mitochondrial function, which plays a crucial role in both aging and longevity. So, if you're interested in incorporating an AKG supplement into your anti-aging routine, Ca-AKG may be worth considering.

Molecular Composition

The molecular composition of Ca-AKG (C5H6CaO6) differs from AKG (C5H6O5) due to the addition of calcium. This results in a compound that is approximately 97% AKG. This higher percentage of AKG contributes to its enhanced effectiveness​​ and may explain why Ca-AKG has higher bioavailability and better anti-aging benefits compared to other forms of AKG.


In summary, Ca-AKG stands out as the superior form of AKG due to its higher bioavailability, longevity and anti-aging benefits, and molecular composition. However, everyone's body is different, and some individuals may respond better to a different form of AKG. It's always best to consult with a healthcare professional before starting any new supplement regimen.

Thank you for reading our comparative analysis of AKG forms. We hope this article has provided valuable information to help you make informed decisions about your health and wellness journey. Stay tuned for more informative articles on our help center page.

Last updated