What is Spermidine? How does it work?

Get an in-depth understanding of Spermidine and how it works.

What is Spermidine?

Spermidine is a natural substance found in our body and in many foods we eat. It's a type of polyamine, a compound made up of several amino groups, that plays a vital role in our health. Initially discovered in semen, spermidine is present in living tissues and helps with various metabolic processes. It's known for its ability to bind to DNA, aid cell growth, and support healthy cell function​​​​.

How Does Spermidine Work?

Spermidine is a natural compound that is found in all living organisms, including humans. It is an essential component for cellular health and has been found to have many beneficial effects on our bodies. In this article, we will explore how spermidine works and its role in promoting overall well-being.

There are three main ways in which spermidine works to improve our health: promoting autophagy, protecting our DNA and cells, and enhancing mitochondrial function. Let's take a closer look at each of these processes.

  • Promoting Autophagy

Spermidine plays a crucial role in promoting autophagy, which is like a recycling process in our cells. This process involves getting rid of damaged or dysfunctional cell parts and replacing them with new, healthier ones. Autophagy is essential for maintaining cellular health and prolonging the lifespan of our cells.

As we age, our cells become less efficient at carrying out autophagy. Spermidine has been found to stimulate this process, ensuring that our cells remain healthy and functional. This is especially important for our brain and heart cells, as they are not easily replaced and need to remain in good condition for optimal functioning.

  • Protecting DNA and Cells

Spermidine also acts as an antioxidant, which means it helps protect our DNA from damage and reduces inflammation. Our DNA is the blueprint for our cells, and any damage to it can have serious consequences for our health.

In addition to protecting our DNA, spermidine also helps safeguard our cells from damage. This is crucial because damaged cells can lead to various health problems, including cancer. By reducing inflammation and protecting our DNA, spermidine plays a crucial role in maintaining stable genetic material and keeping our cells healthy.

  • Enhancing Mitochondrial Function

Mitochondria are the powerhouses of our cells, responsible for producing the energy needed for all cellular processes. Spermidine has been found to enhance the function of mitochondria, leading to increased energy production and improved overall cellular health.

By enhancing mitochondrial function, spermidine can help improve our physical performance and delay age-related decline in energy levels. It also plays a role in maintaining a healthy metabolism, which is essential for weight management and maintaining a healthy body.

Types of Spermidines

There are two main types of spermidine supplements: wheat germ extract and spermidine trihydrochloride. Both of these forms of spermidine have received attention for their potential health benefits, including extending lifespan and health span.

  • Wheat Germ Extract

Wheat germ extract is a rich natural source of spermidine. Wheat germ is the nutrient-rich core of wheat kernels and is processed to extract spermidine, making it a convenient supplement form. This form of spermidine has been used for centuries in traditional medicine and has recently gained popularity for its potential health benefits.

  • Spermidine Trihydrochloride

Spermidine trihydrochloride is a synthetic, water-soluble form of spermidine. It has received attention for its potential health benefits, which include stimulating autophagy, protecting the brain, promoting cardiovascular health, and possessing antioxidant properties. This form of spermidine has been found to be beneficial in extending lifespan and health span across various species, including yeast, nematodes, flies, mice, and potentially humans (r).

Research has shown that spermidine trihydrochloride may also have potential cancer-fighting properties. In one study, it was found to inhibit the growth of cancer cells and increase the rate of cell death. However, more research is needed to fully understand the effects of spermidine trihydrochloride on cancer.

Pure 99% Spermidine Trihydrochloride with Decode Age

Decode Age Spermidine capsules are meticulously formulated to contain 99% Spermidine Trihydrochloride, ensuring a high-quality and effective dose in every capsule. This precise standardization distinguishes our product in the market, offering significantly greater potency compared to competing products like Wheat Germ Extracts, which contain only trace amounts of Spermidine. By choosing Decode Age, consumers benefit from a rigorously developed product that delivers a substantially more concentrated form of Spermidine, enhancing its potential benefits.

Spermidine's Role in Health and Disease

Spermidine is an organic compound, formed through the breakdown of amino acids found in our diet. While it is essential for cell growth and survival, there is growing evidence that suggests spermidine has benefits beyond its basic function. Recent studies have shown that it may also play a critical role in promoting longevity and reducing the risk of age-related diseases. Let's take a closer look at spermidine and its potential role in keeping us healthy.

The Basics of Spermidine

Spermidine is a polyamine, a class of organic compounds that are crucial for cell growth and development. It is present in all living organisms, including plants, animals, and humans. We can obtain spermidine through our diet, particularly in foods rich in protein, such as meat, fish, and eggs. Our bodies can also synthesize spermidine from other amino acids, such as ornithine and putrescine.

  • Fighting Aging

As we age, the levels of spermidine in our bodies naturally decline. This decline has been linked to age-related diseases and conditions, such as liver fibrosis and cancer. However, studies have shown that supplementing with spermidine or consuming spermidine-rich foods may help slow down the aging process and potentially increase lifespan. This is because spermidine has been found to have antioxidant and anti-inflammatory properties, which can protect cells and promote their healthy function.

  • Reducing Disease Risk

In addition to potentially promoting longevity, spermidine may also play a vital role in preventing common age-related diseases. Studies have shown that higher levels of spermidine intake are associated with lower mortality rates from heart disease and cancer. Spermidine has been found to inhibit the growth of tumor cells, which could potentially reduce the risk of developing cancer. It may also help improve cardiovascular health by lowering blood pressure and reducing the risk of atherosclerosis.

Foods Rich in Spermidine

You can increase your spermidine intake by consuming foods like wheat germ, soybeans, nuts, fruits, vegetables, and certain cheeses. These foods not only add variety to your diet but also provide this important compound​​.


Spermidine is a remarkable compound with the potential to improve our health and extend our lifespan. By supporting cellular recycling, protecting DNA, and enhancing energy production in cells, it offers a way to combat age-related diseases and maintain overall wellness. Incorporating spermidine-rich foods into your diet could be a simple yet effective step towards better health and longevity.

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