What is Trans- Resveratrol? And how does it work?

Let’s Talk About Trans-Resveratrol

Trans-Resveratrol is a form of resveratrol, a naturally occurring polyphenol found in various plants. It is known for its potent antioxidant properties and is produced by plants in response to stress. In this article, we will discuss the composition and sources of Trans-Resveratrol, as well as its potential benefits.

Composition and Sources

Trans-Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a part of the stilbenoid group of polyphenols. It is characterized by two phenol rings linked by an ethylene bridge. This compound can be found in more than 70 plant species, including grapes, peanuts, blueberries, and cranberries. It is most commonly found in the skin and seeds of grapes, making it prevalent in red wines and various human foods​.

What is Resveratrol and Why is it Good for You?

Resveratrol is a naturally occurring polyphenol found in numerous plants such as grapes, berries, and peanuts. Polyphenol is a group of phytochemical and micronutrients that are present in plant-based food and drinks. This substance works best as a dietary supplement because it has anticancer, antibacterial, and antioxidant properties. In this article, we will discuss the difference between trans-resveratrol and resveratrol, as well as the benefits of trans-resveratrol.

Resveratrol vs Trans-Resveratrol

Resveratrol has two forms: Cis- and Trans-resveratrol. Trans-resveratrol is the kind of resveratrol that has several potential health benefits because of its structural elements. Since resveratrol has several health benefits (shown in studies), it is often called "nature's immune system."

What is Trans-Resveratrol?

Trans-resveratrol is the active component of resveratrol supplements. This means that trans-resveratrol is the main ingredient responsible for the potential health benefits associated with resveratrol. These benefits may include lowering the risk of developing various diseases such as joint disease, liver illness, Alzheimer’s disease, and more.

What is the Difference Between Trans-Resveratrol and Resveratrol?

Resveratrol vs Trans-Resveratrol

The main difference between trans-resveratrol and resveratrol is that trans-resveratrol is the name of a supplement that contains polyphenols, which are antioxidants. On the other hand, resveratrol is the substance that does all the work. To better understand the difference between the two, let's take a look at the following table:

Trans-Resveratrol and Its Impact on Longevity

Trans-resveratrol is a naturally occurring compound found in various plants, such as grapes, berries, and peanuts. It has attracted a lot of attention due to its potential role in promoting longevity and preventing age-related diseases. One of the ways it achieves this is by interacting with sirtuins, a family of proteins that are closely linked to aging and its related processes. In this article, we will explore the connection between trans-resveratrol and sirtuins and how it impacts longevity.

What are Sirtuins?

Before we dive into the details of how trans-resveratrol interacts with sirtuins, let's understand what these proteins are. Sirtuins are enzymes that are found in all living organisms, from bacteria to humans. They play a crucial role in regulating various biological processes, including metabolism, inflammation, and stress response. These processes are essential in maintaining overall health and preventing age-related diseases.

The Link Between Trans-Resveratrol and Sirtuins

Research has shown that trans-resveratrol can mimic caloric restriction, which is known to increase lifespan in various organisms, including yeast, worms, flies, and fish. This effect is primarily attributed to its ability to activate sirtuins. Among the different types of sirtuins, SIRT1 is of particular interest when it comes to trans-resveratrol. This compound has been found to increase the activity of SIRT1, which plays a crucial role in protecting the body from diseases by enhancing the function of mitochondria.

The Role of SIRT1 in Promoting Longevity

Mitochondria are known as the "cellular powerhouses" as they generate the energy needed for various cellular processes. As we age, the function of mitochondria tends to decline, leading to age-related diseases. By activating SIRT1, trans-resveratrol helps in maintaining mitochondrial health and promoting longevity.

Impact on Biological Mechanisms

Apart from promoting healthy aging, the interaction between trans-resveratrol and sirtuins also influences critical biological mechanisms such as oxidative stress, energy metabolism, nutrient sensing, and epigenetics. These mechanisms play a significant role in aging, and their regulation by sirtuins, particularly SIRT1, is a key factor in the ability of trans-resveratrol to prevent age-related diseases.

The Role of the Sirtuin System

The sirtuin system comprises seven families of regulatory genes and is considered essential in establishing the various health benefits of trans-resveratrol. These genes target the sirtuin class of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, with SIRT-1 being particularly significant in mediating the health and longevity benefits associated with both calorie restriction and trans-resveratrol.

In conclusion, trans-resveratrol's ability to activate sirtuins, particularly SIRT1, is essential in promoting longevity and preventing age-related diseases. By understanding this interaction and its impact on critical biological mechanisms, we can gain a better understanding of how trans-resveratrol can contribute to healthy ageing.

Signs that You Need Trans-Resveratrol

If you are experiencing high blood pressure, cholesterol, or poor blood sugar levels, it may be a sign that you need to start taking trans-resveratrol supplements. Additionally, if you have liver fat issues or high bilirubin levels, trans-resveratrol may be able to help. It is also important to note that while resveratrol can be found in grapes, berries, and wine, it is not possible to get the necessary dosage from these sources. Therefore, it is essential to opt for high-quality supplements, such as liposomal resveratrol, to ensure you are getting the required dosage.

Are Trans-Resveratrol Supplements Safe?

Trans-resveratrol supplements are generally considered safe, especially when consumed in amounts found in foods. Here's a summary of their safety and tips on ensuring the purity of trans-resveratrol supplements:

  1. Low Oral Toxicity: Studies with high-purity trans-resveratrol have shown that it is a substance of low oral toxicity. An acceptable daily intake (ADI) of 450 mg/day has been defined, based on no-observed-adverse-effect-levels (NOAELs)​​.

  2. High Dose Tolerance: A trial evaluating the safety of oral trans-resveratrol found that even a single dose of 5,000 mg resulted in no serious adverse effects​​.

  3. Wide Range of Safe Dosages: Ingested resveratrol at dosages between 6 and 5000 mg per day has been documented as safe​​.

How to Be Sure You Are Purchasing Pure Trans Resveratrol?

  1. Source of Trans-Resveratrol: Japanese Knotweed is a preferred source for high-quality trans-resveratrol supplements due to its high resveratrol content, particularly in its root, ensuring a potent and effective supplement. When selecting trans-resveratrol supplements, checking for Japanese Knotweed as the source can be a reliable indicator of the supplement's concentration and purity.

  2. High Percentage of Trans-Resveratrol: When choosing a supplement, look for a high percentage of trans-resveratrol, as this form is more biologically active. A purity level around 98% is considered excellent​​.

  3. Purity Levels: Resveratrol supplements can vary in purity from 5 percent to 75 percent. Trans-resveratrol is the active ingredient that delivers health benefits, whereas cis resveratrol does not contain beneficial properties​​.

  4. Choosing the Right Supplement: Ensure that the supplement you choose contains trans-resveratrol, as this is the active ingredient. Trans-resveratrol in supplements can contain up to 99% of the active ingredient​​.


In conclusion, resveratrol is a potent antioxidant with numerous health benefits. By consuming a diet rich in fresh fruits and vegetables, exercising regularly, and abstaining from excessive alcohol consumption and smoking, you can maximize the potential benefits of resveratrol. Additionally, opting for high-quality trans-resveratrol supplements, such as Decode Age Trans Resveratrol, can also help ensure that you are getting the appropriate dosage and reaping the maximum benefits.

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