Can I Take Trans Resveratrol? Understanding Dosage and Guidelines

Trans-resveratrol, a naturally occurring phytoalexin produced by plants, has garnered attention due to its potential therapeutic benefits. Research has suggested that it might be beneficial for various clinical conditions including cancer, cardiovascular disease, obesity, diabetes, non-alcoholic fatty liver disease (NAFLD), and neurological diseases​​.


Trans-resveratrol is a compound found in plants that has been studied for its potential health benefits. It is a type of phytoalexin, a substance produced by plants to protect them from diseases and environmental stressors. Trans-resveratrol has shown promise in improving various health conditions and is often sold as a supplement. However, there are important factors to consider before taking it, such as dosage and potential interactions with other medications.

Dosage and Administration

The recommended dosage of trans-resveratrol varies depending on the condition being treated. It is important to follow the recommended dosage stated on the product packaging or consult with a healthcare professional before taking trans-resveratrol.

It is also important to note that resveratrol has a low toxicity level and is reasonably well tolerated up to 5 grams per day. This means that even at higher doses, it is unlikely to cause harmful effects in the body. However, consuming excessively high doses may lead to gastrointestinal issues. It is best to stick to the recommended dosage to avoid any potential side effects.​​


Dosage: The recommended daily dose of trans-resveratrol for adults is between 250mg and 1500mg. It is best to start with a lower dose and adjust as needed, paying attention to your body's response. It is important to note that the recommended dosage may vary depending on the brand and form of trans-resveratrol you are taking.


When Trans-Resveratrol taken with NMN: For the best results, it is recommended to take trans-resveratrol in the morning if it is paired with nicotinamide mononucleotide (NMN). This combination has been shown to have beneficial effects on ageing and related diseases.

if Trans-Resveratrol is taken Alone: If you are taking trans-resveratrol without NMN, it is best to take it in the evening after dinner. This may help to limit any potential side effects and allow the compound to work during the overnight hours.

What other drugs will affect Trans-Resveratrol?

Trans-Resveratrol is a dietary supplement that is commonly used for its antioxidant and anti-inflammatory properties. As with any medication or supplement, it is important to understand if there may be any potential interactions with other drugs.

Currently, there have been no drug interaction studies conducted with resveratrol. However, it is important to consider the potential interaction with blood thinners. Patients taking blood thinning medications such as aspirin, warfarin, or clopidogrel should inform their doctor if they are also taking resveratrol.

If you are taking any other medications, whether prescription or over-the-counter, it is always important to inform your healthcare provider. This includes any dietary supplements you may be taking, such as resveratrol. Your doctor will be able to advise you on the potential interactions and adjust your treatment plan accordingly.

What are the possible side effects of Resveratrol?

As with any medication or supplement, it is important to understand the possible side effects. Fortunately, adverse effects of resveratrol in humans have not been reported. This is supported by a small clinical trial conducted in 2011, which gave 150 mg per day of resveratrol to obese patients and noted no adverse reactions.

However, it is always important to follow recommended dosages and speak with your doctor if you experience any unexpected side effects. Since resveratrol is a relatively new supplement, there may be unknown long-term side effects, so it is important to use it as directed and monitor your health closely.

Contraindications and Interactions

While trans-resveratrol is generally safe for most people, there are certain populations who should avoid taking it. This includes growing children, menstruating females, and individuals with anemia. This is because resveratrol binds to copper and iron, which are important minerals for these groups​​. Additionally, trans-resveratrol may interact with some medications, such as carbamazepine, and other substrates of CYP3A4 enzyme. It is important to consult with a healthcare professional before taking resveratrol if you are currently taking any medication​​.

Clinical Evidence and Therapeutic Potential

Clinical trials have explored resveratrol's effects on various diseases:

  • Cancer: The effectiveness of resveratrol in cancer treatment is inconclusive and varies by cancer type. It has shown potential in delaying cancer recurrence in some cases but not in others. For instance, its impact on prostate cancer is uncertain, with some studies showing potential benefits and others indicating no significant effects​​.

  • Neurological Disorders: Resveratrol shows promise in treating Alzheimer's disease and stroke, with clinical trials indicating its safety and efficacy in modifying disease biomarkers​​​​.

  • Cardiovascular Diseases: It has demonstrated cardioprotective effects in some clinical trials, improving endothelial function and reducing biomarkers of atherosclerosis and inflammation​​​​​​​​.

  • Diabetes: Resveratrol may improve glycemic control and insulin sensitivity, though results are mixed and more research is needed​​.

  • NAFLD: Its effectiveness in treating NAFLD remains inconclusive, with some studies showing positive effects, particularly when used as a supplement to lifestyle changes​​​​.

  • Obesity: Trials have produced mixed results, suggesting that its efficacy might depend on the severity of obesity-related conditions​​.

When considering the use of trans-resveratrol supplements, such as those offered by Decode Age, and NMN (Nicotinamide Mononucleotide), there are specific guidelines on who should avoid these supplements and the optimal times to take them.

Who Should Avoid Resveratrol

  1. Pregnant and Breastfeeding Women: Resveratrol supplements are not recommended for pregnant or breastfeeding women.

  2. Individuals with Bleeding Disorders: People with bleeding disorders should exercise caution or avoid resveratrol due to potential interactions​​.

  3. People Taking Certain Medications: Those on high blood pressure, anti-coagulant, and anti-platelet medications should be cautious. Resveratrol can interact with these drugs due to its blood pressure-lowering and anti-coagulant effects. It also may affect liver medications​​.

  4. Individuals with Hormone-Sensitive Conditions: Since resveratrol can act like estrogen in the body, it's not recommended for women with breast cancer or individuals with a history of estrogen-dependent tumors, including prostate cancer​​.

  5. Pre- and Post-Surgery Patients: Resveratrol should be avoided two weeks before and after surgery due to its anticoagulant properties, which can increase bleeding risk​​.

  6. Individuals with Arthritis or Joint Pain: High doses of resveratrol (more than two grams per day) have been associated with joint pain, resembling arthritic symptoms, in some individuals​​.

  7. Those Prone to Anxiety or Insomnia: Resveratrol may cause jittery feelings similar to excessive caffeine intake and has been reported to cause insomnia in some people​​​​.

  8. People Experiencing Flu-Like Symptoms: Resveratrol can cause muscle aches, cramps, and general malaise in some individuals. If these symptoms persist, it's advisable to stop taking resveratrol​​.

  9. If Experiencing Blood in Urine or Acne: Some individuals may find blood in their urine or develop acne after taking resveratrol. If these symptoms occur, it's recommended to discontinue use and consult a doctor​​​​.

Key Notes:

  1. Start Small: Begin with a 250mg capsule each day after dinner.

  2. Listen to Your Body: See how you feel. If everything seems good, you can gradually increase your dose to 500mg over a few months.

  3. Consistency is Key: Stick with it every day. You might not notice changes overnight, but give it time.

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